发明名称 |
Conjugates of biologically active proteins having a modified in vivo half-life |
摘要 |
Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating peptide motif, wherein the biologically active protein conjugate exhibits a modified plasma half-life compared to the intrinsic half-life of the unconjugated biologically active polypeptide or protein. Also disclosed are methods of making and using the conjugated proteins, as well as methods for determining whether a given conjugate exhibits a modified half life relative to the intrinsic half life of the unconjugated polypeptide. |
申请公布号 |
ZA200707006(B) |
申请公布日期 |
2008.11.26 |
申请号 |
ZA20070007006 |
申请日期 |
2006.01.25 |
申请人 |
CELL THERAPEUTICS, INC. |
发明人 |
BESMAN, MARC;CHIPMAN, STEWART;LEUNG, DAVID;SINGER, JACK |
分类号 |
C07K |
主分类号 |
C07K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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