发明名称 |
Process for the Preparation of 1-Naphthol Mixed Ethers and Intermediates of Crystalline Forms of (+) and (-)-Duloxetine |
摘要 |
The invention relates to a process for the preparation of duloxetine (1a), comprising the reaction between 1-fluoronaphthalene and 3-N,N-dimethylamino-1-(2-thienyl)-propan-1-ol in the presence of 1,3-dimethyl-2-oxo-hexahydropyrimidine (DMPU) as the solvent; a method for the identification of duloxetine enantiomers and for the determination of its optical purity is also disclosed.
|
申请公布号 |
US2008287693(A1) |
申请公布日期 |
2008.11.20 |
申请号 |
US20060090619 |
申请日期 |
2006.10.13 |
申请人 |
FRIGOLI SAMUELE;FUGANTI CLAUDIO;PIZZOCARO ROBERTA |
发明人 |
FRIGOLI SAMUELE;FUGANTI CLAUDIO;PIZZOCARO ROBERTA |
分类号 |
C07D333/20 |
主分类号 |
C07D333/20 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|