发明名称 |
Compositions and methods for sensitizing and inhibiting growth of human tumor cells |
摘要 |
Polynucleotides encoding carboxylesterase enzymes and polypeptides encoded by the polynucleotides which are capable of metabolizing a chemotherapeutic prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing tumor cells to a prodrug chemotherapeutic agent and inhibiting tumor growth with this enzyme are also provided. In addition, screening assay for identification of drugs activated by this enzyme are described.
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申请公布号 |
US7452717(B2) |
申请公布日期 |
2008.11.18 |
申请号 |
US20040858271 |
申请日期 |
2004.06.01 |
申请人 |
ST. JUDE CHILDREN'S RESEARCH HOSPITAL |
发明人 |
DANKS MARY K.;POTTER PHILIP M.;HOUGHTON PETER J. |
分类号 |
C12N15/00;G01N33/50;A61K31/4745;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P35/00;C07H21/04;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/18;C12N15/09;C12N15/55;C12N15/63;C12N15/85;C12Q1/44;G01N33/15 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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地址 |
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