发明名称 |
SCREENING, DIAGNOSING, TREATING AND PROGNOSIS OF PATHOPHYSIOLOGIC STATES BY RNA REGULATION |
摘要 |
A relationship between cancer and ribonucleic acid (RNA) regulation is described by determining intracellular levels of niRN A regulators. Generally, mRNA levels are decreased in cancer cells that may be a reflection of either reduced mRNA expression and/or increased mRNA degradation. miRNAs are identified that hybridize to an mRNA that are suspected to mediate intracellular mRNA steady state levels. Alternatively, ribonucleic acid binding protein (RBP) levels may also mediate intracellular mRNA steady state levels. In particular, this invention demonstrates an effective clinical management strategy for uterine cell cancers may be implemented by taking advantage of an exemplary relationship between P2X<SUB>7 </SUB>mRNA and miRNAs including, but not limited to, miR-186 and/or miR-150. |
申请公布号 |
WO2008115387(A3) |
申请公布日期 |
2008.11.13 |
申请号 |
WO2008US03298 |
申请日期 |
2008.03.13 |
申请人 |
UNIVERSITY HOSPITALS OF CLEVELAND;ROSILAND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE;RIBONOMICS, INC.;GORODESKI, GEORGE;POTASHKIN, JUDY;CHEATHAM, BENTLEY |
发明人 |
GORODESKI, GEORGE;POTASHKIN, JUDY;CHEATHAM, BENTLEY |
分类号 |
C12Q1/70;C07H21/04;C12N15/00;C12Q1/68 |
主分类号 |
C12Q1/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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