| 摘要 |
PROBLEM TO BE SOLVED: To prevent thrombosis without increasing hemorrhage by using a modified annexin protein, preferably annexin V. SOLUTION: The present invention provides a method for screening a modified annexin protein that modulates thrombosis. The method includes: (a) contacting a thrombosis test system with at least one test modified annexin protein under conditions permissive for thrombosis; (b) evaluating antithrombotic activity in the presence of the test modified annexin protein; and (c) comparing the antithrombotic activity in the presence of the test modified annexin protein with the antithrombotic activity in the absence of the test modified annexin protein, wherein a change in the antithrombotic activity in the presence of the test modified annexin protein is indicative of a modified annexin protein that modulates thrombotic activity. COPYRIGHT: (C)2009,JPO&INPIT
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