发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITING ADHESIONS |
摘要 |
The present invention provides compositions and methods for inhibiting adhesions. The methods involve administering solutions containing hydrogel precursors such as polysaccharide derivatives, e.g., derivatives of hyaluronic acid, cellulose, or dextran, to a subject at a site where adhesions may form, e.g., as a consequence of surgery, injury, or infection. The hydrogel precursors, e.g., polysaccharide derivatives, become crosslinked following their administration to form a hydrogel that maintains tissue separation. In certain embodiments of the invention one or both solutions contains particles, e.g., polymeric nanoparticles or microparticles, so that a composite hydrogel containing the particles is formed. The solution(s), particle(s), or both, may contain a biologically active agent such as an agent that contributes to inhibiting adhesions. The biologically active agent may be covalently attached to a hydrogel precursor. |
申请公布号 |
WO2007120818(A3) |
申请公布日期 |
2008.11.06 |
申请号 |
WO2007US09121 |
申请日期 |
2007.04.12 |
申请人 |
THE GENERAL HOSPITAL CORPORATION;E.I. DU PONT DE NEMOURS AND COMPANY;MASSACHUSETTS GENERAL HOSPITAL;YEO, YOON;ITO, TAICHI;LANGER, ROBERT, S.;KOHANE, DANIEL, S.;KODOKIAN, GEORGE, KEVORK |
发明人 |
YEO, YOON;ITO, TAICHI;LANGER, ROBERT, S.;KOHANE, DANIEL, S.;KODOKIAN, GEORGE, KEVORK |
分类号 |
A61F13/00;A01N43/04;A61F2/00;A61K31/715 |
主分类号 |
A61F13/00 |
代理机构 |
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地址 |
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