发明名称 |
MODIFIED FACTOR VIII |
摘要 |
<p>The invention relates to the modification of human Factor VIII (FVIII) to result in FVIII proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo. The invention relates furthermore to T-cell epitope peptides derived from said non-modified protein by means of which it is possible to create modified FVIII variants with reduced immunogenicity.</p> |
申请公布号 |
EP1495052(B1) |
申请公布日期 |
2008.10.29 |
申请号 |
EP20030746308 |
申请日期 |
2003.04.17 |
申请人 |
MERCK PATENT GMBH |
发明人 |
JONES, TIM;BAKER, MATTHEW;CARR, FRANCIS, J. |
分类号 |
C07K14/755;C12N15/09;A61K38/00;A61K38/10;A61K38/36;A61K38/37;A61K39/00;A61P7/00;A61P7/04;A61P37/06;C07K7/08;C12N15/12;C12P21/02 |
主分类号 |
C07K14/755 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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