| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: claimed invention relates to pyperidine derivatives of formula (I) , where R represents galogen or C1-4alkyl; R1 represents C1-4alkyl; R2 or R3 independently represent hydrogen or C1-4alkyl; R4 represents trifluorinemethyl or galogen; R5 represents hydrogen, C1-4alkyl or C3-7cycloalkyl; R6 represents hydrogen, R7 represents radical of formula (W), or R7 represents radical of formula (W) and R7 represents hydrogen; X represents CH2, NR5 or O; Y represents nitrogen, and Z represents nitrogen; or Y represents CH, and Z represents nitrogen; A represents C(O), m is zero or whole number from 1 to 3; t is whole number from 1 to 3; and p and q are whole number from 1 to 2; or to their pharmaceutically acceptable salts and solvates. Claimed invention also relates to method of obtaining said derivatives and to their application for treating condition with tachyquininamia. ^ EFFECT: obtaining pyperidine derivatives, which can be used for treating tachyquininamia. ^ 14 cl, 29 ex, 2 tbl |
