| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a solid catalyst for asymmetric Michael addition reaction easily separated from a product, enhanced in optical purity and prepared in an industrially inexpensive manner, and a manufacturing method of an optically active Michael addition product by the asymmetric Michael addition reaction of a 1, 3-dicarbonyl compound and an enone compound using the solid catalyst for asymmetric Michael addition reaction. <P>SOLUTION: The solid catalyst for asymmetric Michael addition reaction is constituted by fixing lanthanide and an asymmetric carboxylic acid on a carrier comprising hydroxyapatite represented by the general formula (I): Ca<SB>10-z</SB>(HPO<SB>4</SB>)<SB>z</SB>(PO<SB>4</SB>)<SB>6-z</SB>(OH)<SB>2-z</SB>*nH<SB>2</SB>O and/or fluoroapatite represented by the general formula (II): Ca<SB>10-y</SB>(HPO<SB>4</SB>)<SB>y</SB>(PO<SB>4</SB>)<SB>6-y</SB>F<SB>2-y</SB>*nH<SB>2</SB>O both of which are preliminarily treated with the asymmetric carboxylic acid and produced by adding hydroxyapatite represented by the general formula (I) and/or fluoroapatite represented by the general formula (II), both of which are preliminarily treated with the asymmetric carboxylic acid to a solution, which is prepared by dissolving a salt of lanthanide and the asymmetric carboxylic acid in a solvent, to stirr the resulting solution to bond lanthanide to oxygen of phosphoric acid by the ion exchange with calcium of hydroxyapatite and/or fluoroapatite. The manufacturing method of the optically active Michael addition product is characterized in that the 1, 3-dicarbonyl compound and the enone compound are reacted in the presence of the solid catalyst for asymmetric Michael addition reaction. <P>COPYRIGHT: (C)2009,JPO&INPIT |
