发明名称 |
INHIBITION OF HIF-1 ACTIVATION FOR ANTI-TUMOR AND ANTI-INFLAMMATORY RESPONSES |
摘要 |
<p>The presently disclosed subject matter generally relates to methods and compositions for inhibiting the expression and/or activation of hypoxia-inducible factor 1 (HIF-1) genes in a hypoxic cell. More particularly, the methods disclosed herein relate to inhibition of HIF-1 activation in a cell, increasing sensitivity of a tumor cell to radiation and/or chemotherapy, delaying tumor growth, inhibiting tumor blood vessel growth, inhibiting inflammatory responses in a cell through the use of compositions that prevent the nitrosylation of HIF-1, and methods for screening for new inhibitors of HIF-1 activiation. Additionally, the compositions disclosed herein relate to compositions that can be employed in, and are identified by, the disclosed methods.</p> |
申请公布号 |
WO2007123777(A3) |
申请公布日期 |
2008.10.16 |
申请号 |
WO2007US08034 |
申请日期 |
2007.03.30 |
申请人 |
DUKE UNIVERSITY;LI, CHUAN-YUAN;LI, FANG;SONVEAUX, PIERRE;DEWHIRST, MARK, W. |
发明人 |
LI, CHUAN-YUAN;LI, FANG;SONVEAUX, PIERRE;DEWHIRST, MARK, W. |
分类号 |
A61K38/43;A61K49/00;A61P43/00;C12N5/06;C12N15/11;C12Q1/68 |
主分类号 |
A61K38/43 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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