| 摘要 |
In a prefilled syringe separately containing both a lidocaine solution and a hyaluronic acid solution, the viscosity of the hyaluronic acid solution is set so as to be sufficiently higher than the viscosity of the lidocaine solution. When lidocaine discharge from the tip of a hypodermic needle ends, the force f (N) required to discharge the hyaluronic acid solution from the needle tip suddenly increases, imparting sort of a jolt to the hand of the operator and creating a momentary sensation that the plunger is at rest. Letting the force f (N) required to discharge the lidocaine solution be P<SUB>1 </SUB>and the force f (N) required to discharge the hyaluronic acid solution be P<SUB>2</SUB>, the relationship therebetween is P<SUB>1</SUB><P<SUB>2</SUB>. When (P<SUB>2</SUB>-P<SUB>1</SUB>)/P<SUB>2</SUB>>0.2, the operator is able to feel a sufficient jolt.
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