| 摘要 |
PROBLEM TO BE SOLVED: To provide diagnostic screens for Alzheimer's disease, in particular to diagnostic tests based on screening for the presence of cellular changes that occur early in the pathology of Alzheimer's disease. SOLUTION: A method for diagnosis of Alzheimer's disease in a human subject comprises screening for the presence of a cell cycle regulatory defect at the G1/S phase transition in non-neuronal cells such as lymphocyte, dermal fibroblast cells, and carries out screening for the presence of at least one mutation or allelic variant in a gene selected from the group consisting of CDKN3, p15ink4B, p16ink4A, p19ink4D, p27kip1, p21cip1, p57kip2, and TP53. COPYRIGHT: (C)2009,JPO&INPIT |
