| 摘要 |
FIELD: medicine. ^ SUBSTANCE: claimed invention relates to medicine and describes fatty emulsion, containing propofol in concentration from 0.4 to 5 wt/vol %, oil component in concentration from 2 to 5 wt/vol %, and emulsifying agent in concentration from 0.4 to 5 wt/vol % per total amount of fatty emulsion and local anesthetic, mixed with it before application, local anesthetic being mixed with fatty emulsion before application, and fatty emulsion additionally includes stabiliser, selected from the following (a), (b), (c) or (d): (a) at least one phospholipid, selected form group, consisting of phosphatidylglycerine, phosphatide acid, phosphatidylinosite and phosphatidylserine, where fatty acid, complexly eterificated in glycerine fragment, is C10-22 linear or branched, saturated or non-saturated fatty acid; (b) at least one derivative of phospholipid, selected from phosphatidylethanolamines, modified by polyalkylenglycol, where fatty acid, complexly eterificated in glycerine fragment, is C10-22 linear or branched, saturated or non-saturated fatty acid; or (c) at least one fatty acid, selected from group, consisting of C10-22 linear or branched, saturated or non-saturated fatty acids; or (d) mixture of at least two, selected from said above groups(a), (b) and (c),where stabiliser (a), (b) or (c)is present in concentration from 0.01 to 1 wt/vol %, from 0.01 to 1wt/vol %, from 0.05 to 5 wt/vol %, correspondingly, per total; amount of fatty emulsion and local anesthetic, mixed with it before application. ^ EFFECT: ensuring high stability of profol-containing fatty emulsion, with which in advance or before application local anesthetic can be mixed. ^ 34 cl, 16 tbl, 89 ex |
