This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts thereof, wherein R<SUP>12</SUP> is a hydroxylated alkyl group and R<SUP>9</SUP> contains a heterocyclic ring. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating atherosclerosis and preventing atherosclerotic disease events.
申请公布号
WO2008057336(A3)
申请公布日期
2008.09.18
申请号
WO2007US22895
申请日期
2007.10.30
申请人
MERCK & CO., INC.;MORRIELLO, GREGORI, J.;DEVITA, ROBERT, J.;MOYES, CHRISTOPHER, R.
发明人
MORRIELLO, GREGORI, J.;DEVITA, ROBERT, J.;MOYES, CHRISTOPHER, R.