| 摘要 |
The invention provides a process for preparing levofloxacin hemihydrate, comprising: (A) dissolving levofloxacin in a solvent selected from the group consisting of acetonitrile, acetonitrile:H<SUB>2</SUB>O, dimethyl sulfoxide, dimethyl sulfoxide:H<SUB>2</SUB>O, methyl ethyl ketone, methyl ethyl ketone:H<SUB>2</SUB>O, butanol, butanol:H<SUB>2</SUB>O, and mixtures thereof at an elevated temperature; and (B) crystallizing levofloxacin hemihydrate.
|
