THE USE OF VIRULENCE FACTORS OF PATHOGENS TO IMPROVE LIPOSOMAL DELIVERY OF ANTIBIOTICS AND/OR VACCINES

摘要

Liposome encapsulated antibiotic therapy has limited application against infectious organisms which can sequester in non-phagocytic cells. Virulence factors of these infectious organisms, for example bacterial components, when used in the formulation of liposomes can enhance the effectiveness of liposomes as delivery systems in the treatment of disease. In this manner, multi-functional liposomes can be developed to treat target diseases. In addition to serving as antibiotic delivery systems, such liposomes also have an immunization effect. Thus, the liposomes can be used for both the prevention and treatment of diseases.