METHOD FOR ALLEVIATING SIDE EFFECTS OF RETINOIC ACID THERAPYAND/OR IMPROVING EFFICACY WITHOUT INTERFERING WITH EFFICACY
摘要
The invention relates to the use of nicotinic acid alkyl esters, especial ly myristyl nicotinate, to inhibit side effects associated with retinoic aci d therapy. Also a part of the invention is a method for improving skin cell differentiation by administering the nicotinic acid alkyl ester in an amount sufficient to increase expression of caspase 14 and filaggrin. Deficiencies in expression of these molecules can be treated in this way as well.
申请公布号
CA2679315(A1)
申请公布日期
2008.09.04
申请号
CA20082679315
申请日期
2008.02.27
申请人
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION;ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人
COYLE, DONNA L.;KIM, HYUNTAE;COYLE, RUSSELL;JACOBSON, MYRON K.;JACOBSON, ELAINE L.