发明名称 |
PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE 4-HYDROXY-1,2,3,4 -TETRAHYDROQUINOLINES |
摘要 |
<p>The present invention relates to a method for preparing an optically active 4-hydroxy-1,2,3,4-tetrahydroquinoline compound [I], which comprises the steps of:
treating a racemic 4-hydroxy-1,2,3,4-tetrahydroquinoline compound represented by general formula [I]:
[wherein R 1 represents a hydrogen atom or a protecting group for amino group.]
with an enzyme having an ability of selectively or preferentially acylating one enantiomer of the racemic
compound [I] in the presence of an acyl donor; and
if necessary, subjecting the reaction product to solvolysis.</p> |
申请公布号 |
EP1964925(A1) |
申请公布日期 |
2008.09.03 |
申请号 |
EP20060811176 |
申请日期 |
2006.10.04 |
申请人 |
MITSUBISHI TANABE PHARMA CORPORATION |
发明人 |
OKAMOTO, MASAKI;SAKURAGI, AKIRA;KISHIDA, MUNEKI;MORI, YOSHIKAZU |
分类号 |
C12P41/00;A61K31/4709;A61P11/06;C07B51/00;C07B53/00;C07B61/00;C07D215/06;C07D215/08;C07D401/04 |
主分类号 |
C12P41/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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