发明名称 |
Modulation of T cell signaling threshold and T cell sensitivity to antigens |
摘要 |
MicroRNAs (miRNAs) are a diverse and abundant class of ~22-nucleotide (nt) endogenous regulatory RNAs that play a variety of roles in animal cells by controlling gene expression at the posttranscriptional level. Increased miR-181a expression in mature T cells is shown to cause a marked increase in T cell activation and augments T cell sensitivity to peptide antigens. Moreover, T cell blasts with higher miR-181a expression become reactive to antagonists. The effects of miR-181a on antigen discrimination are in part achieved by dampening the expression of multiple negative regulators in the T cell receptor (TCR) signaling pathway, including PTPN22 and the dual specificity phosphatases DUSP5 and DUSP6. This results in a reduction in the TCR signaling threshold, thus quantitatively and qualitatively enhancing T cell sensitivity to antigens.
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申请公布号 |
US2008200416(A1) |
申请公布日期 |
2008.08.21 |
申请号 |
US20070977506 |
申请日期 |
2007.10.24 |
申请人 |
LI QI-JING;CHEN CHANG-ZHENG;DAVIS MARK M;CHAU JACQUELINE |
发明人 |
LI QI-JING;CHEN CHANG-ZHENG;DAVIS MARK M.;CHAU JACQUELINE |
分类号 |
A61K31/70;C12N15/113;C12Q1/68 |
主分类号 |
A61K31/70 |
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