BIOMARKERS OF NEURODEGENERATIVE DISEASE

摘要

The present invention provides biomarkers and diagnostic methods employing such biomarkers based on the discovery of genes that have a two-fold or greater difference in gene expression in the spinal cord of a pre-symptomatic mouse model of amyotrophic lateral sclerosis. Such biomarkers and diagnostic methods are useful for early detection of neural cell injury and death in acute and degenerative disease.