PROTECTIVE AGENT FOR RETINAL NERVE OR OPTIC NERVE

摘要

[PROBLEMS] To provide a protective agent for a retinal nerve or an optic nerve, which exhibits its efficacy through a mechanism that is different fro m that for a conventional therapeutic agent and can be ingested over a long period. [MEANS FOR SOLVING PROBLEMS] Disclosed is protective agent for a ret inal nerve or an optic nerve, which comprises a compound having an inhibitor y activity on an aldose reductase, such as a compound represented by the gen eral formula below, as an active ingredient. Preferably, the compound is (2S ,4S)-6- fluoro-2',5'-dioxospiro[chromane-4,4'-imidazolidine]-2- carboxamide. wherein X represents a halogen atom ora hydrogen atom; R1 and R2 independen tly represent a hydrogen atom or a C1-6 alkyl group which may be substituted , or R1 and R2 together with a nitrogen atom located at the base of R1 and R 2 or additionally together with other nitrogen atom or an oxygen atom may fo rm a 5- to 6-membered heterocyclic ring.