发明名称 |
IDENTIFICATION OF A MICRO-RNA THAT ACTIVATES EXPRESSION OF BETA-MYOSIN HEAVY CHAIN |
摘要 |
The present invention relates to the identification of a microRNA, miR-208, that induces the expression of ß-myosin heavy chain (ß-MHC) and represses fast skeletal muscle contractile protein genes. Inhibition of this function is proposed as a treatment for cardiac fibrosis, hypertrophy and/or heart failure, and augmentation of this function can be used to repress slow fiber genes and activate fast fiber genes in the treatment of musculoskeletal disorders. |
申请公布号 |
WO2008016924(A3) |
申请公布日期 |
2008.08.07 |
申请号 |
WO2007US74866 |
申请日期 |
2007.07.31 |
申请人 |
BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM;OLSON, ERIC;VAN ROOIJ, EVA |
发明人 |
OLSON, ERIC;VAN ROOIJ, EVA |
分类号 |
A61K48/00;A61P9/04;A61P9/10 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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