发明名称 |
STEREOSELECTIVE SYNTHESIS OF 24-HYDROXYLATED COMPOUNDS USEFUL FOR THE PREPARATION OF AMINOSTEROLS, VITAMIN D ANALOGS, AND OTHER COMPOUNDS |
摘要 |
A method is described for stereoselectively reducing an unsaturated alkyl ketone substituent attached to a fused ring base. In this method, the unsaturated alkyl ketone reacts with a chiral oxazaborolidine reagent. This reaction stereoselectively reduces the unsaturated alkyl ketone to an unsaturated alkyl alcohol. The unsaturated alkyl alcohol can be further reduced, if desired, to produce a saturated alkyl alcohol. The fused ring ba se can be, for example, a steroid ring base or a base of a vitamin D analog. Th e process in accordance with the invention can be used with an alkeneone substituent (e.g., a 22-one-24-one substituent) or an alkyneone substituent (e.g., a 22-yne-24-one substituent) on a steroid ring base to make squalamin e or other useful aminosterol compounds and intermediates for making aminoster ol compounds.
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申请公布号 |
CA2272721(C) |
申请公布日期 |
2008.08.05 |
申请号 |
CA19972272721 |
申请日期 |
1997.12.08 |
申请人 |
MAGAININ PHARMACEUTICALS INC. |
发明人 |
BULLIARD, MICHEL;RAO, MEENA N.;ZHANG, XUEHAI;KINNEY, WILLIAM A.;JONES, STEVEN;LEE, NANCY;MECKLER, HAROLD |
分类号 |
C07J9/00;C07J21/00;C07J31/00;C07J41/00;C07J75/00 |
主分类号 |
C07J9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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