CHRONIC REJECTION INHIBITOR

摘要

A study was made on the inhibitory effect of an anti-IL-6 receptor antibo dy on chronic rejection. Specifically, a study was made on the inhibitory ef fect of the administration of an anti-mouse IL-6 receptor antibody (MR16-1) on chronic rejection by using a mouse model of chronic rejection in heart tr ansplantation. A transplanted heart removed 60 days after the transplantatio n was histopathologically analyzed, and it was found that the fibrosis in a cardiac muscle and the vascular restenosis lesion which are characteristic s ymptoms for chronic rejection were significantly inhibited in a group treate d with MR16-1 compared to a control group. Thus, it is confirmed that the ad ministration of MR16-1 can inhibit chronic rejection effectively. That is, i t is found for the first time that rejection in the chronic phase after orga n transplantation can be inhibited by administering an anti-IL-6 receptor an tibody.