Core 2 glcnac-t inhibitors

摘要

Treatments for conditions involving detrimental activity of the enzyme core 2 GlcNAc-T are provided using compounds of the formula I wherein R¹ is H, -OH, C_1-6 alkoxy, -NR⁵R⁶, or Sac 1; R² is H, -OH, C_1-6 alkoxy or Sac 2; R³ is H, -OH, C_1-6 alkoxy or Sac 3; R⁴ is H, C_1-6 alkyl, C_1-6 hydroxyalkyl or C_1-6-alkoxy-C_1-6-alkyl; R⁵ is H, C_1-6 alkyl or C_1-6 acyl; R⁶ is H, C_1-6 alkyl or C_1-6 acyl; Sac 1 Sac 2 and Sac 3 are independently selected saccharide moieties; and Z is a steroid moiety; or a pharmaceutically acceptable salt, ether or ester form thereof.