COMPOSITION COMPRISING CONJUGATE OF STABLE, ACTIVE HUMAN OB PROTEIN WITH ANTIBODY FC CHAIN, AND METHOD

摘要

PROBLEM TO BE SOLVED: To provide OB protein suspensions which are stable and active at physiologic pH useful for the treatment by performing (a) weight control, (b) adiposis control, (c) diabetic alleviation treatment, (d) blood lipid level control, (e) body weight increase except fat or (f) insulin sensitivity increase. SOLUTION: The human OB protein derivatized by bonding Fc region of immunoglobulin with N terminal of OB protein part is provided. COPYRIGHT: (C)2008,JPO&INPIT