发明名称 |
Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture |
摘要 |
The present invention relates to a novel form of cross-linked high amylose starch and processes for its manufacture. Such cross-linked high amylose starch is useful as an excipient in a controlled-release pharmaceutical formulation when compressed with pharmaceutical agent(s) in a tablet. Such cross-linked high amylose starch is prepared by (a) cross-linking and chemical modification of high amylose starch, (b) gelatinization, and (c) drying to obtain a powder of said controlled release excipient. In a preferred embodiment, such cross-linked high amylose starch is prepared in the following steps: (1) granular cross-linking and additional chemical modification (e.g., hydroxypropylation) of high-amylose starch; (2) thermal gelatinization of the starch from step (1); and (3) drying the starch from step (2) to yield a powder capable of being used as a controlled release excipient. |
申请公布号 |
HK1059574(A1) |
申请公布日期 |
2008.06.27 |
申请号 |
HK20040102459 |
申请日期 |
2004.04.06 |
申请人 |
VINCENT LENAERTS;ROLAND HERWIG FRIEDRICH BECK;ELSIE VAN BOGAERT;FRANCOIS CHOUINARD;REINER HOPCKE;CYRIL DESEVAUX |
发明人 |
VINCENT LENAERTS;ROLAND HERWIG FRIEDRICH BECK;ELSIE VAN BOGAERT;FRANCOIS CHOUINARD;REINER HOPCKE;CYRIL DESEVAUX |
分类号 |
A61K;A61K9/00;A61K9/20;A61K9/22;A61K31/137;A61K31/167;A61K31/277;A61K31/496;A61K47/14;A61K47/26;A61K47/36;A61P;C08B33/00 |
主分类号 |
A61K |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|