USE OF CALMODULIN INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS

摘要

The present invention relates to the use of a calmodulin inhibitor/antagonist, like bepridil, phenoxybenzamine, cetiedil, chlorpromazine or W7, for the preparation of a pharmaceutical composition for the treatment, amelioration and/or prevention of neurodegenerative disorders. Also means and methods for the prevention, amelioration and/or treatment of neurodegenerative disorders are described, wherein said calmodulin inhibitor/antagonist is to be administered to a subject in need of such a an prevention, amelioration and/or treatment. Preferably said subject is human and said calmodulin inhibitor/antagonist to be employed in the uses and methods of the invention is bepridil (or a pharmaceutically acceptable salt thereof).