COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT

摘要

The present invention provides a method for treating tumors or tumor metastases in a patient, comprising administering to the patient simultaneously or sequentially a therapeutically effective amount of an anticancer agent and an IGFlR inhibitor compound of Formula (I) combination, with or without additional agents or treatments, such as other anti-cancer drugs or radiation therapy. The invention also encompasses a pharmaceutical composition that is comprised of an anticancer agent and IGFlR inhibitor compound of Formula (I) combination with a pharmaceutically acceptable carrier. The IGFl R inhibitor is represented by Formula (I): wherein X<SUB>1</SUB>, X<SUB>2</SUB>, X<SUB>3</SUB>, X<SUB>4</SUB>, X<SUB>5</SUB>, X<SUB>6</SUB>, X<SUB>7</SUB>, R<SUP>1</SUP>, and Q<SUP>1</SUP> are defined herein.