发明名称 |
Soluble interleukin-1 receptor accessory molecule |
摘要 |
The present invention relates to a novel soluble IL-1 receptor accessory molecule (IL-1R AcM) protein which is a member of the Ig superfamily. In particular, isolated nucleic acid molecules are provided encoding the human IL-1R AcM protein. IL-1R AcM polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Screening methods are futher provided for identifying agonist and antagonists of IL-1 signal transduction. The invention further relates to methods for treating physiologic and pathologic disease conditions with IL-1R AcM antagonists.
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申请公布号 |
US7390880(B2) |
申请公布日期 |
2008.06.24 |
申请号 |
US20050066006 |
申请日期 |
2005.02.25 |
申请人 |
HUMAN GENOME SCIENCES, INC. |
发明人 |
BEDNARIK DANIEL P.;OLSEN HENRIK S.;ROSEN CRAIG A. |
分类号 |
C07K14/00;C07H21/04;C07K14/52;C07K14/715;C12N1/20;C12N15/00;C12N15/85 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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