| 摘要 |
The invention provides a process for preparing Cinacalcet base in which a compound VI, having the structure: where X is C<SUB>1-3 </SUB>alkylsulfonate, substituted and non-substituted C<SUB>6-10 </SUB>aryl sulfonate or halogen, is reacted with (R)-1-Naphthylethylamine and, optionally, a base: 1) under minimal solvent conditions, 2) at a minimum temperature of about 100° C., preferably, greater than 121° C., and, more preferably, at a temperature of greater than 121° C. to about 130° C., and 3) under elevated pressure.
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