发明名称 |
Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
摘要 |
This invention features a method of identifying a compound useful for enhancing efficacy of a therapeutic agent. The method includes incubating a compound in blood cells; separating immune cells from erythrocytic cells; and determining the ratio of the concentration of the compound in the immune cells to the concentration of the compound in the erythrocytic cells; wherein the compound comprises a transportophore and a therapeutic agent, in which the transportophore is covalently bonded to the therapeutic agent via a bond or a linker.
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申请公布号 |
US2008145343(A1) |
申请公布日期 |
2008.06.19 |
申请号 |
US20070895295 |
申请日期 |
2007.08.23 |
申请人 |
BURNET MICHAEL;GUSE JAN-HINRICH;KIM GENE;GUTKE HANS-JURGEN;BECK ALBERT;TSOTSOU GEORGIA;DROSTE-BOREL IRINA;BARKER LAURENCE;WOLF MICHAEL |
发明人 |
BURNET MICHAEL;GUSE JAN-HINRICH;KIM GENE;GUTKE HANS-JURGEN;BECK ALBERT;TSOTSOU GEORGIA;DROSTE-BOREL IRINA;BARKER LAURENCE;WOLF MICHAEL |
分类号 |
A61K35/12;A01N1/02;A61K47/48;A61K49/00;A61P43/00;C12N5/06 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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