IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVE

摘要

A novel low molecular compound which has an action of inhibiting TNF-a production, exerts an excellent effect in a pathological model of inflammatory disease and/or auto-immune disease, has high safety, and can be orally administered is provided. A compound represented by the following general formula (I): [wherein R<SUP>1</SUP> represents a hydrogen atom or a C1-C6 alkyl group, R<SUP>2</SUP> represents a C1-C6 alkyl group which may have a substituent or the like, the ring A represents a benzene ring or the like, X represents a hydrogen atom or 1 to 3 groups, which may be the same or different, selected from the group consisting of a halogeno group, a C1-C6 alkyl group and the like, and Y represents a group represented by -N(R<SUP>3a</SUP>)C(R<SUP>6a</SUP>R<SUP>7a</SUP>)C(R<SUP>8a</SUP>R<SUP>9a</SUP>)N(R<SUP>4a</SUP>R<SUP>5a</SUP>) or the like, (R<SUP>3a</SUP>, R<SUP>4a</SUP>, R<SUP>5a</SUP>, R<SUP>6a</SUP>, R<SUP>7a</SUP>, R<SUP>8a </SUP>and R<SUP>9a</SUP> may be the same or different and represent a hydrogen atom, a C1-C6 alkyl group or the like)], a salt thereof or a solvate thereof, and a TNF-a production inhibitor comprising the compound, a salt thereof or a solvate thereof as an active ingredient.