| 摘要 |
This invention pertains to methods for oligonucleotide synthesis, specifi cally the synthesis of oligonucleotides that contain a high content of guani ne monomers. In more detail, the invention relates to a method for coupling a nucleoside phosphoramidite during the synthesis of an oligonucleotide to a universal support, to a first nucleoside, or to an extending oligonucleotid e. The invention further relates to oligonucleotides obtainable by the metho ds of the invention. |
