| 摘要 |
PROBLEM TO BE SOLVED: To provide materials and methods for treating disease states (including cancer and autoimmune disease) by facilitating or inhibiting the migration or activation of antigen-presenting dendritic cells, since dendritic cells play a critical role in antigen-specific immune responses. SOLUTION: Materials and methods for treating disease states (including cancer and autoimmune disease) are provided by facilitating or inhibiting the migration or activation of antigen-presenting dendritic cells, since dendritic cells play a critical role in antigen-specific immune responses. In particular, chemokines are used to initiate, amplify or modulate an immune response. In one embodiment, chemokines are used to attract dendritic cells to the site of antigen delivery. An increased number of dendritic cells at the site of antigen delivery means more antigen uptake and a modified immune response. COPYRIGHT: (C)2008,JPO&INPIT
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