| 摘要 |
The subject matter of the instant invention is relevant to the prevention of estrogen-dependent conditions such as endometrial hyperplasia and endometrial cancer in patients, including those undergoing hormone replacement therapy. More specifically, the subject matter of the instant invention concerns methods of preventing side effects of unopposed estrogen comprising the pulsatile administration of a progesterone antagonist. The compositions for practicing the methods, comprising progesterone antagonists such as antiprogestins and selective progesterone receptor modulators, which function as progesterone agonists in the uterus and as progesterone antagonists in the breast tissue, are also disclosed. Embodiments of the instant invention also disclose methods for identifying new selective progesterone receptor modulators for practicing disclosed methods of treatment. |
