| 摘要 |
<p>Intermediates and methods for forming passivated surfaces on oxide layers and articles produced thereby are described. Hydroxyl or hydroxide groups o n the oxide surfaces are reacted with a metal reagent of the formula Y(L-Po l)m, where Y is a transition metal, magnesium or aluminum, L is oxygen, sulf ur, selenium or an amine, and "Pol" represents a passivating agent such as a polyethylene glycol, a hydrocarbon, or a fluorocarbon. The resulting modifi ed surface can be further reacted with a passivating agent having a phosphat e functional group or a polyvalent reagent comprising a passivating moiety a nd a plurality of functional groups that are reactive with or that form comp lexes with Y. The passivating agent can also include a functional group such as biotin to provide surfaces with a desired functionality. The passivated surfaces exhibit minimal binding to bio-molecules and can be used in single- molecule detection schemes.</p> |
