COMPOSITION FOR PREVENTING OR TREATING A NEURODEGENERATIVE DISEASE COMPRISING AN EXTRACT FROM A SEED OF PSORALEA CORYLIFOLIA INHIBITING THE ACTIVITY OF BACE-1 OR ACTIVE INGREDIENTS THEREOF

摘要

A composition comprising the extract of Psoralea corylifolia seed or effective compounds contained therein is provided to inhibit the activity of BACE-1(beta-site APP(amyloid precursor protein)-cleaving enzyme 1) mediating the formation of beta-amyloid as a main causing material of dementia, so that the composition is useful for preventing or treating neurodegenerative disease. A composition for preventing or treating neurodegenerative disease comprises the extract of Psoralea corylifolia seed, which is prepared by extracting Psoralea corylifolia seeds with C1-4 alcohol or its solution, dichloromethane, ethylacetate or a mixture thereof, or a compound selected from 7-hydroxy-3-(4-methyl-4-(4-methylpentene-3-yl)-4H-chromen-6-yl)-4H-chromen-4-one represented by the formula(1), bakuchiol, bavachromene, isobavachromene, bavachalcone, isobavachalcone, bavachinin, 7,8-dihydro-8-(4-hydrophenyl)-2,2-dimethyl-2H,6H-[1,2-b:5,4-b']dipyran-6-one isolated from the extract of Psoralea corylifolia seed.