Substituted Thiazoleacetic Acid as Crth2 Ligands

摘要

Compounds of formula (I) are useful for the treatment of disease responsive to modulation of CRTH2 receptor activity, such as asthma, rhinitis, allergic airway syndrome, and allergic rhinobronchitis; wherein X₁ is -S-, -O-, -N-N-. -NR₇-, -CR₇-CR₈-, -CR₇-N-, wherein R₇ and R₈ are independently hydrogen or C₁-C₃ alkyl; A is a carboxyl group -COOH, or a carboxyl bioisostere; rings Ar² and Ar³ each independently represent a phenyl or 5- or 6-membered monocyclic heteroaryl ring, or a bicyclic ring system consisting of a 5- or 6-membered carbocyclic or heterocyclic ring which is benz-fused or fused to a 5- or 6-membered monocyclic heteroaryl ring, said ring or ring system being optionally substituted; ring B is as defined for Ar² and Ar³, or an optionally substituted N-pyrrolidinyl, N-piperidinyl or N-azepinyl ring; s is 0 or 1; L1, L2 and L4 are linker radicals as defined in the description; Q₁ and Q₂ represent substituents as defined in the description.