| 发明名称 |
TREATMENT OF RHEUMATOID ARTHRITIS WITH SOLUBLE FAS-LIGAND CROSS-LINKERS |
| 摘要 |
The invention encompasses novel methods of treating rheumatoid arthritis and its symptoms and novel methods of identifying and screening for drugs useful in the treatment of rheumatoid arthritis and its clinical symptoms. Targeted manipulation of a computer model of a human rheumatic joint provided the surprising result that cross-linking soluble Fas-ligand (sFasL) has a significant impact on the pathophysiology of rheumatoid arthritis. The symptoms of rheumatoid arthritis may be alleviated by administering a sFasL-specific cross-linker.
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| 申请公布号 |
US2008118466(A1) |
申请公布日期 |
2008.05.22 |
| 申请号 |
US20070760599 |
申请日期 |
2007.06.08 |
| 申请人 |
ENTELOS, INC. |
发明人 |
HUREZ VINCENT JACQUES;MICHELSON SETH G.;SHODA LISL KATHARINE;STRUEMPER HERBERT;WENNERBERG LEIF GUSTAF |
| 分类号 |
A61K38/16;A61K31/445;A61K31/4985;A61K31/513;A61K31/704;A61K31/7088;A61K33/24;A61K38/17;A61K38/19;A61K38/21;A61K39/395;A61K48/00;A61P19/02;C07K16/28;G01N33/53 |
主分类号 |
A61K38/16 |
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