<p>The present invention provides glucoimidazole derivatives and methods of making them. The compounds can be used to inhibit the activity of O-GlcNAcase enzymes, including both bacterial OGA (bOGA) and human OGA (hOGA) and can be selective, showing low inhibition of hexosaminidases. The compounds can be used to study the role of the O-GlcNAcase modification in human or animal cells. Furthermore the compounds can have therapeutic uses in the treatment of diseases mediated by the activity of O-GlcNAcase enzymes including type II diabetes, Alzheimers Disease, and cancer.</p>
申请公布号
WO2008059267(A1)
申请公布日期
2008.05.22
申请号
WO2007GB04384
申请日期
2007.11.15
申请人
THE UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE;VAN AALTEN, DANIEL, MARINUS;BORODKIN, VLADIMIR, SERGEEVICH;DORFMULLER, HELGE
发明人
VAN AALTEN, DANIEL, MARINUS;BORODKIN, VLADIMIR, SERGEEVICH;DORFMULLER, HELGE