发明名称 |
Methods for identifying compounds that modulate DeltaTRalpha2 activity |
摘要 |
Truncated thyroid hormone receptors DeltaTRalpha1 and DeltaTRalpha2 have been discovered to play a role in actin-based endocytosis, e.g., in the nervous system. The invention relates to methods of discovering ligands effective in modulating endocytosis and transgenic mice with altered expression of DeltaTRalpha1 and DeltaTRalpha2. The invention is useful for the discovery and testing of compounds for treating disorders of the nervous system such as depression.
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申请公布号 |
US7374890(B2) |
申请公布日期 |
2008.05.20 |
申请号 |
US20040822591 |
申请日期 |
2004.04.12 |
申请人 |
UNIVERSITY OF MASSACHUSETTS |
发明人 |
LEONARD JACK L.;FARWELL ALAN P. |
分类号 |
G01N33/50;G01N33/53;G01N33/566;G01N33/567;G01N33/68;G01N33/78 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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