摘要 |
A method of treating a subject in need of therapy for a condition involving detrimental activity of the enzyme core 2 GlcNAc-T is provided, comprising administration of a therapeutically effective amount of an inhibitor of core 2 GlcNAc-T of formula I to a patient in need thereof wherein: R<SUP>1 </SUP>is H, C<SUB>1-6 </SUB>alkyl, C<SUB>1-6 </SUB>hydroxyalkyl, C<SUB>1-6 </SUB>alkoxy or C<SUB>1-6</SUB>-alkoxy-C<SUB>1-6</SUB>-alkyl; R<SUP>2 </SUP>is H, -OH or C<SUB>1-6 </SUB>alkoxy; S<SUP>1 </SUP>and S<SUP>2 </SUP>are independently selected saccharide moieties; and Z is a steroid moiety; or a pharmaceutically acceptable salt, ether or ester thereof. |