| 发明名称 |
Methods of using G-CSF analog compositions |
| 摘要 |
The present invention relates to granulocyte colony stimulating factor ("G-CSF") polypeptide analog compositions. The concept detailed herein provides methods for screening G-CSF analogs, designed with one or more substitutions to amino acids, and selecting analogs for use as G-CSF replacements or antagonists, and may be generalizable beyond G-CSF analogs as well. In addition, pharmaceutical compositions and methods of use are provided for analogs so selected.
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| 申请公布号 |
US7371370(B2) |
申请公布日期 |
2008.05.13 |
| 申请号 |
US20040910087 |
申请日期 |
2004.08.03 |
| 申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
SARKAR CASIM A.;LAUFFENBURGER DOUGLAS A. |
| 分类号 |
A61K38/19;C12N15/09;A61K38/00;A61K45/00;A61P7/00;A61P7/04;A61P7/06;A61P15/00;A61P25/00;A61P31/00;A61P31/18;A61P35/00;A61P37/00;A61P37/04;A61P43/00;C07K14/535;C12N1/19;C12N1/21;C12N5/078;C12N5/10;C12P21/02;C12Q1/02 |
主分类号 |
A61K38/19 |
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