| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to synthesis of heterocyclic compounds, which contain pyrrolo[1,2-][1,4]diazepine fragment, annelated to aromatic and heteroaromatic ring. Method for preparation of derivatives of pyrrolo[1,2-][1,4]diazepine of general formula I, where = ^ , is described. The said derivatives may be of use as substances with potential CNS activity, or with analgesic, antimicrobial and antifungal effect. Method implies recyclization of furan ring of 5-methyl-furfurylamides of general formula 2, , where stands for above shown groups, by exposure to temperature of 60-70° in the mixture of glacial acetic acid and strong hydrochloric acid in volumetric ratio 1:0.15 for 10-15 minutes. ^ EFFECT: provides for simultaneous formation of pyrrole and diazepine rings and improves yield of end products due to less number of process steps. |
