| 摘要 |
Oligonucleotides having the ability to stimulate osteogenesis in vertebrate animals, including humans, are disclosed. These osteogenic oligonucleotides can be used in a wide range of clinical procedures to replace and restore osseous and periodontal defects or to facilitate the successful implantation of prosthesis and distraction procedures in bones. Methods for generation of bone in an area of an animal where skeletal tissue is deficient are provided. They consist in the local or systematic administration of a composition comprising one or more of the osteogenic oligonucleotides to the animal, in a pharmaceutically acceptable carrier. The composition is administered in an amount effective to induce osteogenesis at the bone site.
|
