| 摘要 |
<p>A series of Z-stilbenes derivatives, which have the structure as shown by formula 1 <EMI ID=1.1 HE=65 WI=69 LX=498 LY=867 TI=CF> <PC>```wherein X is hydrogen, NH2 or nitro group. Y or Z is independently hydrogen, halogen, C1-C10 alkyl, or C1-C10 alkoxyl and A is hydrogen, hydroxyl, or amino group. The compounds of the present invention have both aqueous solubility and anti-tumor activity. The Z-stilbene derivatives of the present invention can further include a pharmaceutical carrier to form pharmaceutical composition to provide a potent anti-mitotic and anti-cancer agent, by inhibiting cellular mictrotubule polymerization.</p> |
