HCl POLYMORPHS OF 3-(2-(DIMETHYLAMINO)METHYL(CYCLOHEX-1-YL))PHENOL

摘要

Crystalline hydrochloric acid salts (A') of 3-((2-dimethylaminomethyl )-cyclohexyl)-phenol (I) with hydrochloric acid are new, where ratio hydrochloric acid : (I) is specifically 1:1. Independent claims are included for: (1) new hydrates of (A'), having a water of crystallization content of 1-10 (especially 7-8) wt. % based on the hydrate; (2) five new crystalline polymorphic forms of (A'), designated forms I, II, III, IV and V (form V being a hydrate) and characterized by X-ray diffraction patterns and Raman spectra; and (3) preparation of the new polymorphic forms of (A'). - ACTIVITY : Analgesic; Antidepressant; Neuroprotective; Antiparkinsonian; Nootropic; Anticonvulsant; Tranquilizer; Antitussive; Uropathic; Antidiarrheic; Antipruritic; Neuroleptic; Cerebroprotective; Relaxant; Anorectic; Immunomodulator; Antialcoholic; Antismoking; Antiaddictive; Antidiuretic; Cardiant; Aphrodisiac; Local anesthetic. - MECHANISM OF ACTION : None given in the source material.