A PROCESS FOR THE PREPARATION OF CARVEDILOL

摘要

The present invention provides a more simplified, cost effective, commercially feasible process for the preparation of Carvedilol (I) comprising a step of reacting 4-hydroxy oarbazole (II) with epichlorohydrin and directly isolating the intermediate 4-(2,3- epoxypropoxy) carbazole (III) which on purification followed by reaction with 2-(2- methoxyphenoxy) ethylamine (IV) yields crude Carvedilol (I). The crude Carvedilol (I) is converted to pure product either through solvent crystallization (without salt formation) or through salt formation followed by salt cleavage and solvent crystallization resulting in highly pure (i.e. ICH grade) Carvedilol.