INHIBITORS OF CONVENTIONAL PROTEIN KINASE C ISOZYMES AND USE THEREOF FOR TREATING INFLAMMATORY DISEASES
摘要
<p>The present invention relates to the use of an inhibitor that inhibits a conventional protein kinase C alpha isozyme and/or of an inhibitor that inhibits a conventional protein kinase C alpha isozyme and that inhibits a conventional protein kinase C gamma isozyme as a medicament or for the preparation of a medicament for treating inflammatory diseases, in particular inflammatory diseases that are mediated by a Toll-like receptor 2 (TLR-2) and/or an Interleukin-1 receptor (IL-1R). The present invention further provides suitable inhibitors for use in the present invention; pharmaceutical compositions and kits for treating such TLR-2 and/or IL-1R mediated inflammatory diseases.</p>
